playground: a short track of a drumbox and a Minimax stereo pair (each)
the game: after recording to VDAT (32 bit) the tracks were played back through parallel channels of the 2448 mixer, the Asio track phase inverted, basic latency compensation by a stereo delay, fine compensation by sample delay of the mixer channel.
result: perfect phase extinction to a faint white noise (level full up)
this suggests you will NOT loose any quality for the fact alone you passed it to the Asio driver.
nevertheless there will be an advantage (to be expected) on complex mixes by an increased headroom of the 32bit data, but that ASIO for itself spoils the sound is a myth imho.
comments welcome, in particular if someone sees a flaw in the setup - it ran a bit too straight forward

cheers, Tom