Your hardware is similar to mine. The biggest difference is your OS (I'm using WinME).
But I remember experiencing the same problem about a year or so ago (in addition to what I believed was a ground loop problem). I tried every possible "fix" known to man including, but not limited to:
1) replacing the mobo, processor & RAM
2) replacing the monitor (with a flat LCD model)
3) replacing the PS two or three times (now using a 400W silent model)
4) replacing the tower case with an industrial-style rack-mount case
5) dressing the wiring inside the case in such a way that everything was out of the way and neat
6) using rounded IDE cables on my drives
7) tweaking the OS (tried every possible tweak known to man)

Tried a Furman balanced power supply (this was an expensive and very heavy unit that I bought from and ultimately returned to Musician's Friend)
9) I may have tried a regular (non-optical) mouse at one point and that didn't resolve the problem either
10) Partitioning my hard drive so I could have a separate OS for recording and another for general purpose (internet) work.
I literally broke my entire studio down to a few pieces (PC, monitor, mouse, keyboard, mixer) and moved it to other locations in my house. We didn't use the dining room table for about a week while I was poking around at the guts of my PC. I had make-shift ground wires running from the PC to the sink in the kitchen and other parts of the house. It was a trip man, let me tell you. I spent hours scouring the internet looking for any reference material I could find on the subject of PC audio noise. I can tell you there is a lot of voodoo out there. In fact I think I actually hired a witchdoctor to come dance around the table at one point. I was willing to try anything
After beating my head against the wall for about a month or so, most of my noise problems seemed to disappear when I:
1) Bought and installed an A16 Ultra
2) Used the Firewire interface instead of the ADAT optical interface
3) installed some Ebtech hum eliminators between my PC and my mixer
Those last 3 items reduced my noise floor to practically nothing and I considered my problem resolved. These were guerilla tactics to be sure. All I can say is good luck!
PS: that little red happy face you see above is the result of trying to type "8" and the ")" character together. I guess this BBS must think I'm trying to be funny. I'm not.
<font size=-1>[ This Message was edited by: krizrox on 2003-10-07 15:02 ]</font>